Amphiphysin antibody
recognises 128 kDa protein and has a similar cerebellar distribution as
GAD antibody.
Such autoimmunity (amphiphysin
antibodies) to brain tissue can cause paraneoplastic stiff persons syndrome and can be
associated with tumours of the breast and small cell lung carcinomas.
Amphiphysin antibody can be
associated with Stiff-persons syndrome and various other neurological
conditions.
Image: Primate cerebellum showing staining of the
granular layer with nuclei in red.
